Hosted on MSN

Researchers decode tertiary structure of DNA aptamer–ATP complex and improve binding affinity

DNA aptamers are powerful molecular tools in biosensing, bioimaging and therapeutics. However, a limited understanding of their tertiary structures and binding mechanisms hinders their further ...

How RNA binding selectivity arises from disordered regions

RIKEN researchers have discovered how an enzyme modifies gene expression by targeting certain stretches of messenger RNA ...
BioTechniques

DNA and RNA methylation directly linked for the first time

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...
The Conversation

RNA is key to the dark matter of the genome − scientists are sequencing it to illuminate human health and disease

Marlene Belfort does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond ...
EurekAlert!

A single-site DNA–histone cross-link causes a global breakdown of nucleosome structure and function

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...