Nature

In vitro selection of aptamers and their applications

The introduction of the in vitro evolution method known as SELEX (systematic evolution of ligands by exponential enrichment) more than 30 years ago led to the conception of versatile synthetic ...
Nature

Integrated Microfluidic Isolation of Aptamers Using Electrophoretic Oligonucleotide Manipulation

We present a microfluidic approach to integrated isolation of DNA aptamers via systematic evolution of ligands by exponential enrichment (SELEX). The approach employs a microbead-based protocol for ...
Labroots

WEBINAR: CE-SELEX: Isolating High Affinity Aptamers Using Capillary Electrophoresis

SELEX is a process that selects DNA or RNA from a random library of sequences based on their affinity for a target molecule. These high affinity ligands, called aptamers, have great potential for use ...
EurekAlert!

Fig. 2 Cell-SELEX method for screening Melapts. Melapts that specifically bind melanopsin were selected by Cell-SELEX because melanopsin is a membrane protein bound to and ...

(A) DNA aptamers were selected using the Cell-SELEX method from a random ssDNA library. DNA aptamers were mixed and bound to (−) melanopsin cells (negative selection). When unbound DNA aptamers were ...