Almost all mammalian cell types have morphologies that are uniquely tailored to their physiological functions. This immense variation in cell shape depends on an underlying network of dynamic and ...

Podocyte injury and loss are critical events in diabetic nephropathy (DN); however, the underlying molecular mechanisms remain unclear. Here, we demonstrate that asparaginyl endopeptidase (AEP) ...

Nephropathy is a major complication of diabetes. Alterations of mesangial cells have traditionally been the focus of research in deciphering molecular mechanisms of diabetic nephropathy. Injury of ...

Our kidneys are charged with the extraordinary task of filtering about 53 gallons of fluid a day, a process that depends on podocytes, tiny, highly specialized cells in the cluster of blood vessels in ...

The kidneys are vital organs that sustain life by filtering the blood and producing urine. This filtration process takes place in specialized structures called glomeruli, where podocytes play a ...

A single podocyte was reconstructed in three dimensions based on serial glomerular section images obtained by array tomography. The three-dimensional reconstruction enabled quantitative volume ...

A fasting-mimicking diet may promote renoprotection by reducing proteinuria and improving endothelial function. Cycles of controlled fasting may promote regeneration of podocytes in patients with ...

Senior Postdoctoral Research Fellow, GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Children's Hospital Los Angeles The glomerular filtration barrier, generated ...