Protocadherins, a subfamily within the cadherin superfamily, are fundamental to the precise organisation of neural circuits. They contribute to cell adhesion mechanisms that underlie synaptic ...

Cheng Lyu is the winner of the 2025 Eppendorf & Science Prize for Neurobiology for her work in understanding how neural circuits assemble with such remarkable precision during development. Neural ...

Researchers from Kyushu University discovered a previously unrecognized synaptic "hotspot" that forms during adolescence, challenging the long-held view that adolescent brain development was dominated ...

A detail of a figure from the paper shows synapses formed between a neuron (above) and muscle (below) a narrow cleft. The distinct T-bar shape indicates an active zone. In the upper image, the synapse ...

Adolescence is widely thought to be a time when the brain trims away excess neural connections, refining circuits through synaptic pruning. New research now suggests this view may be incomplete.

A cross-disciplinary team led by Prof. Qu Jianan from the Department of Electronic and Computer Engineering and Prof. Julie L. Semmelhack from the Division of Life Science at The Hong Kong University ...

Scientists studying human neural organoids could only record and stimulate activity from limited regions because conventional flat electronics do not conform well to the tissues’ three-dimensional, ...

I have spent many years as a psychiatrist being frustrated at the lack of treatment options for patients with terribly debilitating psychiatric illnesses.” — Dr. Mary L. Phillips, Distinguished ...

In the 1970s and ‘80s, scientists began noticing that people who had few or poor social relationships had a higher risk of developing illnesses and all-cause mortality. 1,2 A slew of follow-up studies ...

Neuropathic pain, caused by injury or disease of the somatosensory nervous system, is a major clinical challenge and often evolves into a chronic condition. Importantly, up to 80% of patients with ...