Engineered blood vessels harness artificial intelligence (AI) and magnetoelasticity to continuously monitor blood flow and stenosis in real time.

Ovrlpy identifies overlapping cell signals in the vertical dimension of spatial transcriptomics data.

Barcoding microbial ribosomal RNA creates a record of gene transfer events without requiring translation. Kalvapalle et al. designed catalytic RNAs to barcode host RNA upon gene transfer, allowing ...

An illustration of lipid nanoparticles (green circles) targeting the lung, designed using neural networks. Witten et al. present a method (LiON) using neural networks for lipid discovery and ...

A model of two zinc-finger nucleases bound to DNA overlaid on an image of a metaphase chromosome spread. The side chains shown are key to the dimer interface of the cleavage domains, according to ...

Optimizing guide RNA design for Cas13. With data from massively parallel screens, Wessels et al. develop computational models to identify optimal guide RNAs for the RNA-targeting CRISPR enzyme Cas13d.

Wearable sensors are evolving to provide accurate, continuous and wireless monitoring of our health and disease states. Using designs and materials that interface seamlessly with skin, accessing a ...

Antisense oligonucleotides are commonly generated as mixtures of a vast number of stereoisomers. A scalable chemical method (p 845) now provides control over phosphorothioate stereochemistry, enabling ...

Scanning electron micrograph of a heart-forming organoid showing a myocardial layer (pink) separated by a thin endocardial layer (blue) from an anterior foregut endoderm and vascular layer (cinnamon); ...

Artwork by Pamela Goode. Neuron- and glia-like cells derived from induced pluripotent stem cells promise tractable, individualized human models of Alzheimer's, Parkinson's and amyotrophic lateral ...

Artist’s impression of a protein translocating through a nanopore. Yu et al. identify conditions that allow complete proteins to translocate through a nanopore when driven by an electroosmotic effect.

Analogs of the pancreatic peptide hormone amylin are making strides in obesity as developers zoom in on oral drugs that can emulate or even improve on injectable GLP-1 agonists while avoiding muscle ...