Mitochondria are cellular organelles that play an important role in making ATP (adenosine triphosphate), the molecular fuel that powers most cellular functions. These organelles originated over a ...

Mitochondria are essential organelles whose functions span energy conversion, metabolism and signalling. Most of their 1,000–1,500 proteins are synthesised in the cytosol and rely on an intricate ...

A team at ETH Zurich has identified clumping of a protein called GRK2 inside neurons as a distinct driver of Alzheimer’s-related brain damage, separate from the amyloid plaques that most current ...

Calcium transport into and out of mitochondria is central to cellular energy production and cell death. To maintain the balance of calcium within mitochondria, cells rely on a protein known as the ...

Scientists uncovered how the amino acid leucine enhances mitochondrial efficiency by preserving crucial proteins that drive energy production. By downregulating the protein SEL1L, leucine prevents ...

In a new study, researchers from Japan demonstrate that COX7RP, a mitochondrial protein, may play a key role in enhancing mitochondrial energy efficiency, leading not only to longer lifespans but also ...

Our cells produce a variety of proteins, each with a specific role that, in many cases, means that they need to be in a particular part of the cell where that role is needed. One of the ways that ...

Copper is essential for life. Our cells need the metal to make energy and stay healthy, but if it is in the wrong place or ...

The green fluorescent signal indicates the stability of mitochondrial surface proteins (marked in red). Changes in cellular nutrient levels, such as the availability of leucine, alter the signal’s ...

As life expectancy continues to climb globally, the focus of many people has moved from longevity alone to living in good health. This has drawn attention to the need to extend "healthspan," the ...