APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have intrinsic dinucleotide ...

DNA sits in sunlight every day, absorbing ultraviolet radiation that can set off the kind of chemical changes linked to ...

Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...

The DNA base cytosine has a lot of different outfits in its closet. Most famously, the base can slip on a methyl group at its fifth carbon, a change that lends cytosine the ability to silence genes.

Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations. Early life forms on Earth are likely to have mutated and evolved at much higher ...