Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...
Caspase-1 is a prototypical inflammatory caspase central to innate host defence and inflammatory homeostasis. Upon detection of microbial or danger signals by pattern-recognition receptors of the ...
Most unnecessary or dangerous cells such as virus-infected cells commit suicide by activating an in-built suicide program. This type of cell death is referred to as "programmed cell death". Until ...
Most unnecessary or dangerous cells such as virus-infected cells commit suicide by activating an in-built suicide program. This type of cell death is referred to as "programmed cell death". Until ...
A small-molecule inhibitor of caspase-1 has a seemingly large effect in a mouse model of Alzheimer’s disease. Researchers led by Andréa LeBlanc of McGill University in Montreal reported in the ...
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