Workflow to perform snRNA-seq of different WAT depots. The nuclei were derived from subcutaneous (S), epididymal (E), mesenteric (M), peri-nephritic (N), and peri-heart (H) adipose depots, which were ...

Adipose tissue is a highly dynamic organ whose cellular composition and functional capacity adapt continuously to nutritional status, environmental stimuli and developmental cues. Within both white ...

Adipose tissue functions as a dynamic organ that both stores energy and orchestrates systemic metabolism through the regulated handling of fatty acids. Under conditions of energy surplus, adipocytes ...

A team of scientists has identified an unexpected embryonic "starting point" for several brown-fat depots: a small cell niche around the dorsal aorta. Using a combination of time-controlled genetic ...

In a recent preclinical study published in the Journal of Clinical Investigation, researchers in the United States of America investigated the role of the transcription factor KLF15 (short for Kruppel ...

The common forms of type 2 diabetes are caused by a constellation of genetic and epigenetic factors and molecular changes related to diet; lifestyle, including lack of exercise and sleep; ...

Adipose tissue is a cellular mosaic. To make sense of it—and gain a better understanding of metabolic conditions such as obesity—the different tiles need to be distinguished, no matter how alike they ...

Adipose tissue biology has undergone a paradigm shift, revealing this tissue as a highly dynamic and metabolically active organ that is central to both ...

Abdominal fat is not a uniform tissue. A new study from Karolinska Institutet, Steno Diabetes Center Copenhagen, and Helmholtz Munich reveals that fat located close to the large intestine contains an ...

The researchers analyzed data from the C4R study, incorporating participants from the Jackson Heart, CARDIA, MESA, and ...

Adipose tissue is an important regulator of metabolism and energy homeostasis in the human body. It is usually classified into two distinct categories: white adipose tissue (WAT) and brown adipose ...