Five signaling subtypes identified by NMF clustering. Subtype 5 (high APsig) correlates with immune-rich "hot" tumors, while Subtype 2 (low APsig) exhibits metabolic reprogramming and hypoxia. High ...

St. Jude Children's Research Hospital scientists have discovered how tumors disable immune "gatekeeper" cells that alert the ...

Early-stage cancer immunotherapy represents a promising yet underexplored frontier in cancer research. While immunotherapeutic strategies have achieved ...

Tumors driven by cancer-driving KRAS mutations are often susceptible to ferroptosis, a type of cell death that can be ...

WATERTOWN, Mass. and GOSSELIES, Belgium, April 07, 2024 (GLOBE NEWSWIRE) -- iTeos Therapeutics, Inc. (ITOS), a clinical-stage biopharmaceutical company pioneering the discovery and development of a ...

In the field of neuro-oncology, the dual topics of cellular metabolism and the tumor microenvironment (TME) have gained ...

The inflammatory tumor microenvironment (TME) is a complex network of cancer, immune, and stromal cells interacting through cytokines and growth factors to drive tumor growth, angiogenesis, and immune ...

Existing oncology therapeutics are either so specific they can target only part of a tumor, or so generalized they kill healthy tissue. A new “Tumor Activated Therapy™” in development at the small ...

St. Jude Children's Research Hospital scientists have discovered how tumors disable immune "gatekeeper" cells that alert the rest of the immune system to the presence of cancer - and how restoring ...

The adenosinergic system, principally mediated by four subtypes of G-protein-coupled adenosine receptors (A1, A2A, A2B and A3), plays a pivotal role in the regulation of immune responses.

Advances in tissue-based technology in the past few years have created unprecedented opportunities to identify biomarkers of disease processes, especially within oncology by using multi-omics ...